منابع مشابه
Vessel-widening by VEGF
A group of epithelial cells in the thymus guard against autoimmunity by presenting self-antigens to developing T cells—those T cells that take the bait are then killed. On page 1267, Rossi et al. identify the signaling pathway that creates this epithelial barrier and the cells that activate this pathway. Self-reactive T cells are eliminated when they latch on to selfantigens presented by a smal...
متن کاملAxial vessel widening in arborescent monocots.
Dicotyledons have evolved a strategy to compensate for the increase in hydraulic resistance to water transport with height growth by widening xylem conduits downwards. In monocots, the accumulation of hydraulic resistance with height should be similar, but the absence of secondary growth represents a strong limitation for the maintenance of xylem hydraulic efficiency during ontogeny. The hydrau...
متن کاملTwo ways VEGF-A builds a vessel
n page 1163, Gerhardt et al. present a mechanism to explain the function of VEGF in angiogenesis. Their findings implicate a specialized cell at the tips of vessels in guiding the growth of new sprouts, with cell mass provided by the division of different cells that lie further back. The authors examined angiogenesis in mice retina. Retinal O Tip cell (green) filopodia follow VEGF-A–expressing ...
متن کاملReversible retinal vessel closure from VEGF-induced leukocyte plugging.
Clinical trials in patients with macular edema due to diabetic retinopathy or retinal vein occlusion (RVO) have shown that suppression of VEGF not only improves macular edema, but also reopens closed retinal vessels, prevents progression of vessel closure, and improves retinopathy. In this study, we show the molecular basis for those clinical observations. Increased retinal levels of VEGF in mi...
متن کاملMural Cell Associated VEGF Is Required for Organotypic Vessel Formation
BACKGROUND Blood vessels comprise endothelial cells, mural cells (pericytes/vascular smooth muscle cells) and basement membrane. During angiogenesis, mural cells are recruited to sprouting endothelial cells and define a stabilizing context, comprising cell-cell contacts, secreted growth factors and extracellular matrix components, that drives vessel maturation and resistance to anti-angiogenic ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2007
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.2046iti4